Which type of biopsy requires specialized methods for cell preservation?

• A. Skin biopsy
• B. Bone marrow biopsy
• C. Blood biopsy
• D. Hair follicle biopsy

Answer: (B)

The correct response is the bone marrow biopsy, which necessitates specialized methods for cell preservation due to the nature of the tissue being sampled. Bone marrow contains a variety of cells, including hematopoietic stem cells, which must be preserved in a way that maintains their viability and functionality for accurate diagnostic evaluation.

Specialized techniques, such as the use of specific anticoagulants and immediate processing of samples, are required to ensure that these cells do not degrade before analysis. This is critical for identifying various hematologic disorders, as the cellular architecture and integrity are vital for obtaining meaningful test results.

Other types of biopsies, while they may have their own preservation considerations, typically do not require the same level of specialized methods as bone marrow biopsies due to differences in tissue structure and the types of cells involved.